The Immunohistological Comparison of the Number of Gingival Blood Vessels Between Type 2 Diabetes Mellitus and Chronic Periodontitis Patients Tip 2 Diabetes Mellitus ve Erişkin Periodontitis Hastalarında Dişeti Damar Sayısının İmmünohistokimyasal Olarak Karşılaştırılması

نویسندگان

  • Dilek ŞENGÜN
  • Gürhan ÇAĞLAYAN
  • Alp USUBÜTÜN
  • İlker ETİKAN
  • Nezaket ADALAR
چکیده

ÖZET Aim: The study was designed for comparatively analyze the number of vessels in gingival biopsies from type 2 Diabetes Mellitus (DM) with or without periodontitis and from systemically healthy subject with or without periodontitis. Subjects and Methods: A total of 88 individuals, 24 being type 2 DM patients with periodontitis (DP), 21 being type 2 DM patients with periodontal health (DH), 25 patients with chronic periodontitis (CP) and 18 subjects with clinical and systemic health (C), were included in the study. Biopsies from attached gingiva of all patients were obtained from maxillary canine and premolars. Sections were immunohistochemically stained for CD34 positive cells and hematoxylin-eosin. Results: The results indicated that in DP groups, the mean number of blood vessels was found to be significantly higher than that of DH, CP and C groups (p≤0.05). In the CP group, number of blood vessels was higher than DH and C groups (p≤0.05) and there was no statistically significant difference between DH and C groups (p>0.05). When the number of blood vessels are considered within groups, comparisons Amaç: Bu araştırma, Tip 2 Diabetes Mellitus (DM) hastalarında periodontitis varlığında ve yokluğunda dişetindeki damar sayısının sistemik açıdan sağlıklı periodontitisli ve periodontal sağlığa sahip bireylerle karşılaştırmak üzere planlandı. Bireyler ve Yöntem: 24 Tip 2 DM’li ve periodontitisli (DP), 21 Tip 2 DM’li periodontal sağlıklı (DH), 25 kronik periodontitisli (CP) ve 18 hem periodontal hem de sistemik açıdan sağlıklı (C) toplam 88 bireyle yürütüldü. Örnekler hematoksilen-eozin ve immünohistokimyasal olarak CD34 ile boyandı. DP grubunun mikrovasküler yoğunluk değeri DH, CP ve C gruplarından, yüksek bulundu (p≤0.05). CP değerleri de DH, C den yüksekti (p≤0.05) ama DH ve C grupları arasında önemli bir fark yoktu (p>0.05). DP ve CP hastalarında 2. ve 3. derece iltihap varlığında kaydedilen ortalama damar sayısı değerleri arasında anlamlı bir fark izlenmedi (p>0.05). DP hastalarında diyabetin neden olduğu komplikasyonlarla damar sayısı arasında ilişki tespit edilemedi. Hacettepe Dişhekimliği Fakültesi Dergisi Cilt: 31, Sayı: 1, Sayfa: 52-60, 2007 The Immunohistological Comparison of the Number of Gingival Blood Vessels Between Type 2 Diabetes Mellitus and Chronic Periodontitis Patients Tip 2 Diabetes Mellitus ve Erişkin Periodontitis Hastalarında Dişeti Damar Sayısının İmmünohistokimyasal Olarak Karşılaştırılması *Ayşegül KARAKUŞ DDS, PhD, *Dilek ŞENGÜN DDS, PhD, *Atilla BERBEROĞLU DDS, PhD, *Gürhan ÇAĞLAYAN DDS, PhD, **Alp USUBÜTÜN DDS, PhD, ***İlker ETİKAN DDS, PhD, ****Nezaket ADALAR DDS, PhD *Hacettepe University, Faculty of Dentistry, Department of Periodontology **Hacettepe University, Faculty of Medicine, Department of Pathology ***Hacettepe University, Faculty of Medicine, Department of Biostatistic ****Hacettepe University, Faculty of Medicine, Department of Endocrinology

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تاریخ انتشار 2007